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Fertility factor
The Fertility factor (first named F by one of its discoverers Esther Lederberg) allows genes to be transferred from one bacterium carrying the factor to another bacterium lacking the factor by conjugation. The F factor is carried on the F episome, the first episome to be discovered. Unlike other plasmids, F factor is constitutive for transfer proteins due to the gene ''traJ''. The F plasmid belongs to a class of conjugative plasmids that control sexual functions of bacteria with a fertility inhibition (Fin) system.
== Discovery of Fertility factor "F" ==
Esther M. Lederberg and Luigi L. Cavalli-Sforza discovered "F," 〔As written by Esther Lederberg: "At this same time, L. Cavalli in Milan Italy, discovered the phenomenon of sterility from a different angle. Exchange of data showed that if I had done an experiment, he had planned to do it, but had completed another that we had planned. So we decided to pool forces and collaborate." See http://www.estherMlederberg.com/Clark_MemorialVita/HISTORY52.html〕 subsequently publishing with Joshua Lederberg.〔Lederberg, J., Cavalli, L. L., and Lederberg, E. M., Nov. 1952, "Sex compatibility in Escherichia coli", Genetics 37(6):720-730〕 Once her results were announced, two other labs joined the studies. "This was not a simultaneous independent discovery of F (I names as Fertility Factor until it was understood.) We wrote to Hayes, Jacob, & Wollman who then proceeded with their studies."〔http://www.estherMlederberg.com/Clark_MemorialVita/Eric%202%20FFactor5.html〕 The discovery of "F" has sometimes been confused with William Hayes' discovery of "sex factor", though he never claimed priority. Indeed, "he () thought F was really lambda, and when we convinced him (it was not ), he then began his work."〔http://www.estherMlederberg.com/Clark_MemorialVita/Eric%201%20FFactor5.html〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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